Free USPS First Class Shipping on all kratom. Priority Shipping option for $8
Free USPS First Class Shipping on all kratom. Priority Shipping option for $8

News Detail

Top Pick Kratom Stack

Top Pick Kratom Stack

People have been searching online for Kratom stacks and we have been working hard to bring you the best!  In this article, our affiliate Liftmode talks about Kratom + Agmatine stacks and how to use this powerful neurotransmitter supplement together with Kratom. Learn about the benefits of mitigating kratom tolerance, lowering required amounts, and more!

 

Agmatine is a popular pre-workout stack that helps with increasing energy and physical performance.  Many users also report that Agmatine is effective for reducing stress and supporting a healthy mood.  In addition, it has neuroprotective and cardioprotective benefits. Agmatine, as a standalone, is a Chakra Corner top pick for well-being supplements and may also help to support healthy cognition and memory.

What is Kratom?

Kratom (Mitragyna speciosa) is a tropical plant that is indigenous to Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea.  At low serving sizes, Kratom is said to have energizing and alertness-enhancing effects, while larger servings are used for calming, relaxation, and pain relief.

Although Kratom is beneficial to most people who use it, it can cause problems if it is misused. When taken in excess, Kratom stimulates receptors in the brain called opioid receptors. These receptors are also the targets for certain pain-relief medications as well as a number of illicit substances.[2]

 

 

As with all compounds that stimulate opioid receptors, too much Kratom can cause respiratory depression (slow, shallow breathing). When combined with alcohol or other sedatives, this can be very dangerous to your health. A number of deaths have been linked to Kratom, but almost always when combined with alcohol or opioid medication.[3]

Daily use of Kratom can cause tolerance to build fairly quickly. This means that a larger serving is required to experience the same effects as before. Naturally, this comes with a greater risk of adverse effects. Furthermore, once tolerance has developed, if you stop using Kratom right away, you may be in for a nasty, and dangerous surprise – known as Kratom withdrawal.[4]

 

 

Although there is not yet any research published on the combination of Agmatine and Kratom, animal studies and anecdotal reports from the internet indicate a positive relationship.

In one study, researchers examined the effects of Kratom on dependence and tolerance to morphine, in mice. The results showed that Agmatine not only blocked the development of tolerance but also increased the pain-relief effects by a factor of 3.[5]

Clearly, this is a very interesting relationship that might even extend to other pain-relief substances (including Kratom). However, more research is needed to properly understand these effects and how they might work in humans.

In one online forum, a Kratom user posted his experience combining with Agmatine:

 “…1.5g now achieves the same effect as 3g for me and is perhaps still too much. All I did was add agmatine. It’s got a long half-life of what I think might be 10 hours where it exerts its actual effect on NMDA receptors...”[6]

On another forum, a user posted a similar experience:

“Twice today I tried 500 mg of agmatine sulfate 30 min before burning kratom… With the NGSMD it made it more uplifting with slightly more enjoyment. This evening with the RHB I am feeling quite content and have a feeling of well-being…  Agmatine is supposed to reduce tolerance and I think it just may.”[7]

 

 

There appears to be at least a moderate positive relationship between the two, with Agmatine improving the effects of Kratom, reducing the required amount to feel desirable effects, and thereby decreasing the risk of developing tolerance.

 

RefereMnces:fo on Agmatine including stacks, usage, and more; visit our friends at LiftMode!

 

References:

[1] Fluyau, D., & Revadigar, N. (2017). Biochemical Benefits, Diagnosis, and Clinical Risks Evaluation of Kratom. Frontiers in psychiatry8, 62.

[2] White, C.M. (2017). Pharmacologic and clinical assessment of kratom. Am J Health Syst Pharm. 2018 Mar 1;75(5):261-267. Review.

[3] US Food and Drug Administration. (2018). Statement from FDA Commissioner Scott Gottlieb, M.D., on the agency’s scientific evidence on the presence of opioid compounds in kratom, underscoring its potential for abuse. Fga.gov [online] Available at: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm595622.htm

[4] Singh, D., Müller, C.P., Vicknasingam, B.K. (2014). Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users. Drug Alcohol Depend, 1;139:132-7.

[5] Li, J., Li, X., Pei, G., Qin, B.Y. (1999). Effects of agmatine on tolerance to and substance dependence on morphine in mice. Zhongguo Yao Li Xue Bao.

[6] Agmatine sulfate is amazing for tolerance. (2017). Reddit.com [online]. Available at: https://www.reddit.com/r/kratom/comments/7lck4q/agmatine_sulfate_is_amazing_for_tolerance/

[7] Agmatine Sulfate. (2015). Ilovekratom.org [online]. Available at: http://www.ilovekratom.com/kratom-forum/kratom-discussion/2748-agmatine-sulfate

[8] Kamel, P. (2018). Creatine. Examine.com [online] Available at: https://examine.com/supplements/creatine/

[9] Bemben, M.G., Lamont, H.S. (2005). Creatine supplementation and exercise performance: recent findings. Sports Med, 35(2):107-25.

[10] Uzbay, T., Kose, A., Kayir, H., Ulusoy, G., Celik, T. (2010). Sex-related effects of agmatine on caffeine-induced locomotor activity in Swiss Webster mice. Eur J Pharmacol, 25;630(1-3):69-73.

[11] Is agmatine good with caffeine? (2016). Reddit.com [online] Available at: https://www.reddit.com/r/Nootropics/comments/595u8z/is_agmatine_good_with_caffeine/

[12] Yang, X.C., Reis, D.J. (1999). Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neurons. J Pharmacol Exp Ther. 288(2):544-9.

[13] Diler, A.S., Ziylan, Z.Y., Üzüm, G. (2013). N-methyl-D-aspartate Receptors Are Involved in Caffeine-Induced Facilitation on Memory Retention of Passive Avoidance Learning in Rats. Journal of Caffeine Research, 3:4, 169-174

[14] Kamel, P. (2018). Arginine. Examine.com [online] Available at: https://examine.com/supplements/arginine/

[15] Kamel, P. (2018). Citrulline. Examine.com [online] Available at:  https://examine.com/supplements/citrulline/

[16] Kamel, P. (2018). Agmatine. Examine.com [online] Available at: https://examine.com/supplements/agmatine/